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Image Search Results
Journal: Acta Cirúrgica Brasileira
Article Title: Licorice zinc suppresses melanogenesis via inhibiting the activation of P38MAPK and JNK signaling pathway in C57BL/6J mice skin
doi: 10.1590/acb371002
Figure Lengend Snippet: Licorice zinc inhibited UVB-induced JNK/P38MAPK signaling pathway activation. C57BL/6J mice skin was treated with UVB, mice were given licorice zinc (0.65 g/kg, 1.3 g/kg, 2.6 g/kg) and 250mg tranexamic acid once a day. (a) JNK/ P38MAPK signaling pathway-related proteins were analyzed by western blotting using antibodies against JNK, p-JNK, P38MAPK, and p-P38MAPK, β-actin served as a loading control. (b) The ratio of p-JNK/ JNK and p-P38MAPK/ P38MAPK were quantified by western blotting analysis and normalized to control.
Article Snippet: Then, probed with
Techniques: Activation Assay, Western Blot
Journal: Acta Cirúrgica Brasileira
Article Title: Licorice zinc suppresses melanogenesis via inhibiting the activation of P38MAPK and JNK signaling pathway in C57BL/6J mice skin
doi: 10.1590/acb371002
Figure Lengend Snippet: Inhibition JNK pathway restrained UVB--induced melanin formation. After B16F10 cells were cultured for 24 h, cells were treated with 0.1 mM α-MSH for 72 h, meanwhile, cells were treated with licorice zinc negative serum, 10% licorice zinc positive serum, and 10% licorice zinc positive serum+Anisomycin. The Control group was cultured with nothing except medium all along. (a) The content of melanin was measured by sodium hydroxide dissolution. (b) JNK/ P38MAPK signaling pathway and melanin productionrelated protein were an alyzed by western blotting using antibodies against JNK, p-JNK, P38MAPK, pP38MAPK, TRP-1, tyrosinase, and MTIF. β-actin served as a loading control. (c) The relative density of TRP1, tyrosinase, and MTIF, and the ratio of p-JNK/ JNK and p-P38MAPK/ P38MAPK were quantified by western blotting analysis and normalized to control.
Article Snippet: Then, probed with
Techniques: Inhibition, Cell Culture, Western Blot